Vol. 12, Issue 5, Part A (2025)

Author(s): Umar Aliyu, Zainab Tukur, Aliyu Abdulhamid Omar and Auwal Alhassan Barde

Abstract: Aedes aegypti is a mosquito that is responsible for the spread of so many arboviral diseases such as yellow fever, zika and chikungunya which have recently drawn attention globally because of their rapid spread. The best way to control vectors that these arboviral diseases is the use of synthetic insecticides, however insecticides resistance may arise from indiscriminate use of these insecticides against Aedes aegypti. The present study was designed to evaluate insecticides resistance and to detect the knockdown resistance (kdr) mutations in Aedes aegypti of Bauchi State, North-eastern Nigeria. Mosquito larvae were collected from five Local Governments Areas across the state using ovitraps from April - September 2023 and evaluated against five main classes of insecticides using WHO bioassays. Larval bioassay revealed that Aedes aegypti larvae from all locations are susceptible to both temephos and deltamethrin except from larvae from Alkaleri that showed high resistance to deltamethrin (LC50 = 0.0193 mg/L RR = 18.2). Aedes aegypti adult showed moderate resistance towards the tested insecticides especially pyrethroids (deltamethrin and permethrin). Permethrin resistance populations from Misau and Ganjuwa Local Governments and deltamethrin resistance populations from Misau, Alkaleri, and Katagum Local Governments showed full susceptibility recovery following pre-exposure to PBO, indicating the involvement of cytochrome P450 monoxygenases. Aedes aegypti from Bauchi State was discovered to have the F1534C knockdown resistance mutation. Findings from this study will therefore help to design and implement insecticides resistant management interventions against Aedes aegypti and to improve yellow fever and dengue control in the state.

DOI: 10.22271/23487941.2025.v12.i5a.862