Zika virus is the mosquito-borne Flavivirus which may develop Zika syndrome, it develops psychiatric illness, featured through microcephaly along with mental complication and even also death of foetus. First Zika virus is recognised from mosquito species Aedes africanus in the Ziika forest of Uganda. In general, ZIKV are very much prominent among affected healthy children and adults by skin rashes along with trouble in joints, conjunctivitis, malaise, headache that are present for 2 to 7 days. In case of pregnant women, complications of this virus are congenital brain disorder and ocular imperfection in foetus, faultiness of brain including microcephaly besides ocular obstruction like microphthalmia, weakness in optic nerve, cataracts are also recognised. Some bioactive constituent like nutraceuticals have immense effect to protect human from Zika virus manifestation including Brazilian peppertree fruit peel extract, isoquercitrin, curcumin, Docosahexaenoic acid (DHA) and soon.