Current understanding of the pathogenesis of Dengue virus infection and therapeutic diet for controlling associated symptoms
Author(s): Souvik Tewari, Prathiksa Pramanik, Madhumita Mondal and Ranajit Kumar Khalua
Abstract: In modern decades, Dengue virus is very much serious concern in both developing and developed countries. In tropical areas, 75% occurrence of Dengue are present, among them most of the infestations are lenient to immunosuppressed besides 5% occasion of Dengue infections are chronic. Persistent Dengue infections have many serotypes of Dengue virus. The seriousness of Dengue is hanged on various mechanism of immunopathogenic including host and viral agents. Pathophysiology of Dengue virus can be depended on alteration of T cells, immunopathology of antibody, cytokine storm. Manifestations of Dengue are agony in bones, muscles, joints, headache, temperature of fever is 40 °C, macular skin infestations, small haemorrhagic infections including purpura, malaise, petechiae, ecchymosis, epistaxis, haematuria, gums bleeding, aches. Dengue virus infections are present about 3 to 7 days approximately. Dietary modification is very much needed to balance the manifestation of Dengue. The therapy of macrophages must be started through modifying the concentration of butyrate along with specifically manage the ratio of Bacteroidetes and Firmicutes which lesions the activity of proinflammatory mediators for instance NO, IL-6, IL-12 with the help of suitable dietary pattern. Noteworthy, adequate amino acids, dietary fibre, Poly Unsaturated Fatty Acid (PUFA), Mono Unsaturated Fatty Acid (MUFA), vitamins, polyphenols and other bioactive components are very much closely associated in monitoring the homeostasis of macrophages in intestine. This review is the sum up of pathophysiology, symptoms along with dietary strategy of Dengue virus.