Vol. 10, Issue 4, Part A (2023)

Author(s): P Astalakshmi, M Basheera John, Kavinilavu G and D Vimala

Abstract: Culex quinquefasciatus, the "southern house mosquito" is a tiny to medium-sized mosquito that resembles Cx. pipiens Linnaeus, the "northern house mosquito." Where they overlap (36°–39° north latitude), they can interbreed, and intermediate species may result. Gram-negative, pleomorphic, non-spore-forming, and possessing a monotrichous flagellum, Aeromonas hydrophila is a bacillus. It is a facultative anaerobe that is frequently found in sewage as well as fresh water. In this investigation, the effectiveness of the chemical compound, Hexadecanoic acid (Carica papaya) was determined on the two species mentioned above. The insilico procedure was used to investigate Hexadecanoic acid's anti-microbial and insectide capabilities based on the comparison study. This study's technique included automated drug docking procedures and protein profiling research. All of the findings were shown in 3D. Hexadecanoic acid's effectiveness in binding to the Outer Membrane Protein Transport Protein of Culex quinquefasciatus and Aeromonas hydrophila was clearly demonstrated by the comprehensive molecular interaction analysis. Hexadecanoic acid was ultimately shown to have a better inhibitive effect on Aeromonas hydrophila than on Culex quinquefasciatus. Therefore, Hexadecanoic acid has the potential to treat illnesses brought on by Aeromonas hydrophila.

DOI: 10.22271/23487941.2023.v10.i4a.680