Vol. 10, Issue 3, Part A (2023)

Author(s): P Astalakshmi, M Basheera John, Kavinilavu G and D Vimala

Abstract: Aedes aegypti is known to spread diseases by acting as a vector for Yellow fever virus, Dengue virus, Chikungunya virus, and Zika virus. Aeromonas hydrophila is a bacillus with a monotrichous flagellum which is gram-negative, pleomorphic and non-spore-forming. It is a facultative anaerobe that is commonly present in both fresh water and sewage. In this research study, we found out the efficiency of the chemical molecule, Pentane (Phyllanthus emblica) on the above two species. From the comparative study, we analyse the anti-microbial and Insecticide properties of Pentane using insilico protocol. The methodology of this study involved protein profiling studies and automated drug docking protocols. All the results were elucidated in 3D form. The complete molecular interaction study clearly elucidated the efficiency of the molecular compound, Pentane with the target proteins, Mucin-5AC and the Outer Membrane Protein Transport Protein of Aedes aegypti and Aeromonas hydrophila respectively. It was finally concluded that Pentane had better inhibitive action on Aeromonas hydrophila than on Aedes aegypti. Hence, Pentane acts as a potential therapeutic agent for diseases associated with Aeromonas hydrophila.

DOI: 10.22271/23487941.2023.v10.i3a.678