Effect of feeding of Anopheles arabiensis patton (Diptera: Culicidae) on ivermectin treated–rabbit blood
Author(s): Nagla MY Ramadan, Nabil HH Bashir and Bakri YM Nour
Abstract: Anopheles mosquitoes (Diptera: Culicidae (are the main vectors of malaria. Innovative approaches are needed. The use of endectocides, e.g. ivermectin, could be a new addition of antimalarial measures. Some authors reported that Anopheles mosquitoes is particularly sensitive to very low concentrations of ivermectin relative to other vectors. The present work aimed to investigate the possibility of mortality of An. arabiensis adults after feeding on ivermectin-treated rabbits blood at different exposure periods and testing 3 doses (recommended =1ml/50kg body weight, 25% lower and 25% higher), determining the time required for mortality and to the effective dose. Mosquito were starved for 24 hr and fed on the rabbits. Rabbits were divided into group in 4 cages, 2 /cage one of the for the untreated control. To each cage 10 starved females were introduced and with the rabbits inside the cage for 1hr for feeding, then removed. The number of dead adults was recorded at 24, 48, 72, 96, 120 and 144 hr, and 2, 3 and 4 wk. Also, the Knock-down time (KdT) for the different treatments was calculated. The first part of the experiment (1st injection; phase 1) continued for 28 Days, followed by 21 days withdrawal, and the 2nd injection. The same parameters were taken. The experiment was repeated twice. The results showed that the recommended dose was more effective than the other 2 doses in terms of mortality rates during the 1st month, but in the 2nd month the 125% treatment resulted in better effect. However, it is concluded that ivermectin treatment on rabbits did not show promising effects.
How to cite this article:
Nagla MY Ramadan, Nabil HH Bashir, Bakri YM Nour. Effect of feeding of Anopheles arabiensis patton (Diptera: Culicidae) on ivermectin treated–rabbit blood. Int J Mosq Res 2019;6(6):85-89.