Larvicidal activity of temephos released from new chitosan/alginate/gelatin capsules against Culex pipiens

Authors:Mohamed E. I. Badawy, Nehad E. M. Taktak, Osama M. Awad, Souraya A. Elfiki, Nadia E. Abou El-Ela

A new controlled release capsules based on chitosan, alginate, and gelatin crosslinked with glutaraldehyde and loaded with the insecticide temephos were prepared and assessed against Culex pipiens larvae. Capsules were characterized with respect to their size, shape, larvicide loading, swelling, and in vitro and in vivo release kinetics. Capsules were loaded with temephos 7.35% as determined by UV spectroscopy. The highest in vitro release amount of the insecticide was found at the first day. The in vivo release data showed that the capsules reached to a plateau at the first day with the highest weight of the capsules, resulting in a highest mortality (100%). These studies revealed that the release kinetic showed high efficacy against the larvae that showed 100% mortality up to 120 and 92 days with 0.05 g of capsules in the stagnant and running water experiments, respectively. It could be concluded that the new capsules based on the biodegradable polymers containing temephos could be effective as controlled release formulation against C. pipiens larvae for long time.

 

 

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