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International Journal of Mosquito Research
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International Journal of Mosquito Research
Vol. 5, Issue 4, Part A (2018)

Synthesis, molecular docking and insecticidal activity evaluation of chromones of date palm pits extract against Culex pipiens (Diptera: Culicidae)

Author(s): Mohamed A Hussein, Ola H Zyaan, Abo-bakr H Abdel Monsef, Sameh A Rizk, Shaimaa M Farag, Soryia E Hafez, Amany S Khaled and Omnia M Helmy
Abstract: Agricultural wastes may provide natural alternative to mosquitoes control because of their bioactive components. The current study involved evaluation of the toxicity of date palm pits extracted in methanol 70% against third larval instar of Culex pipiens. Methanolic extract of date palm pits via HPLC yielded two novel chromone flavonoid compounds; chromone 1 and chromone 2. These chromone derivatives were synthetically prepared under laboratory conditions. Results showed that chromone 1 and chromone 2 exhibited excellent insecticidal activity against third larval instar of Cx. pipiens after 24 hours of treatment at LC50 32.359 and 38.717 ppm, respectively and great inhibition of AChE with value -61.48 and -60.45 %, respectively compared to control. Chromone 1 and chromone 2 were theoretically evaluated for interactions with acetylcholinesterase (AChE) using in silico molecular docking techniques. Both experimental and in silico results showed that chromone 1 exhibited higher activity than chromone 2. These results proved that, the chromone derivatives considered to be inhibitors for AChE enzyme in Cx. pipiens.
Pages: 22-32  |  382 Views  43 Downloads
How to cite this article:
Mohamed A Hussein, Ola H Zyaan, Abo-bakr H Abdel Monsef, Sameh A Rizk, Shaimaa M Farag, Soryia E Hafez, Amany S Khaled and Omnia M Helmy. Synthesis, molecular docking and insecticidal activity evaluation of chromones of date palm pits extract against Culex pipiens (Diptera: Culicidae). International Journal of Mosquito Research. 2018; 5(4): 22-32.
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